Science
Researchers develop AI tool to map microRNA binding sites on circular RNAs
Source: Phys.org · Published
Circular RNAs (circRNAs) are loop-shaped molecules that can influence gene regulation through interactions with microRNAs (miRNAs). This matters because circRNAs can exist as different full-length isoforms, and their back-splice junction (BSJ) connects the two ends of the RNA. Treating a circular RNA like a linear transcript can therefore overlook sequence information near this junction.
Key points
- Circular RNAs (circRNAs) are loop-shaped molecules that can influence gene regulation through interactions with microRNAs (miRNAs).
- This matters because circRNAs can exist as different full-length isoforms, and their back-splice junction (BSJ) connects the two ends of the RNA.
- Treating a circular RNA like a linear transcript can therefore overlook sequence information near this junction.
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